TK Maxx will be occupying a shop in Barnstaple in time for spring 2015.
British Land, which owns Green Lanes Shopping Centre, has confirmed the retailer will move into a purpose-built, two-storey extension on a 15-year lease.
The store will carry the full TK Maxx range, including womenswear, menswear, footwear and accessories.
Planning approval for the unit was secured last year and construction will start in spring this year.
The store is scheduled to open in spring 2015.
Ailsa Davidson, asset manager for British Land, said: “The arrival of TK Maxx at Green Lanes is great news, strengthening the centre’s already strong fashion credentials, and demonstrating its ability to attract leading occupiers.”